Hello Devs, This will be a quick post - but another reminder that you need to do your research and not take the first result to fix a problem as gospel. I was about to run a server test to my latest application in VirtualBox, when I suddenly got the following error: The virtual machine 'Node' has terminated unexpectedly during startup with exit code 1 (0x1). More details may be available in 'C:\Users\jesse\VirtualBox VMs\node\Logs\VBoxHardening.log'. Result Code: E_FAIL ( 0x80004005 ) Component: MachineWrap Interface: IMachine {...} So - what happened? Microsoft came out with a new security update: KB4043961 . First advice might be to uninstall it -- don't. As annoying as they can be, security updates are essential. So I have found the better solution is to upgrade the version of VirtualBox. Download this version ( 5.2.2-119230 ), and you'll be fine.